Chris Masterjohn — Oxidative Stress & Carbohydrate Intolerance: An Ancestral Perspective

Chris Masterjohn, Ph.D. has just completed his Ph.D. at the University of Connecticut, where his doctoral research focused on the role of oxidative stress in regulating metabolism of methylglyoxal, a major precursor of advanced glycation end products. He created and maintains Cholesterol-And-Health.Com, where he publishes his blog, The Daily Lipid.

The role of carbohydrate in health and disease remains controversial in the ancestral health community. Numerous groups of foragers, pastoralists, and agriculturalists have been found free of the so-called “diseases of civilization” while subsisting on diets rich in carbohydrate, yet clinical trials have shown that low-carbohydrate diets can help reduce disease risk in modernized populations. In this talk I will discuss evidence from my doctoral research suggesting that oxidative stress contributes to carbohydrate intolerance and will review the literature suggesting that oxidative stress is a common cause underlying carbohydrate intolerance in modernized populations. I will conclude by presenting a broad, holistic view of “oxidative stress” that moves beyond “antioxidants” and focuses instead on the density and balance of nutrients in the diet, and the optimization of the hormonal milieu within which those nutrients operate.

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